Endocrine Abstracts

The sustained over-secretion of PTH is a common clinical problem with particular consequences for the skeleton. Hyperparathyroidism (HPT) increases the bone surface undergoing remodelling, amplifies the negative balance at the bone multicellular unit and increases activation frequency, eroded surface and formation, without increased trabecular perforation. Cortical bone is particularly susceptible to the effects of hyperparathyroidism and bone mineral density (BMD) measurement...